PRF Therapy: 3 Ways It's Different from PRP

If you’ve been exploring treatments to rejuvenate your skin or address hair loss, you’ve probably come across platelet-rich plasma (PRP) therapy. But have you heard about platelet-rich fibrin (PRF) therapy?

PRF therapy is taking the dermatology world by storm — and for good reason! It offers a range of benefits that set it apart from PRP.

At HK Dermatology in San Juan Capistrano, California, our dermatology providers are committed to providing the most effective therapies available to boost your skin and hair health.

That’s why we’re excited about PRF therapy. Like PRP therapy, this next-generation injectable treatment is derived from your blood and uses the healing properties of platelet and growth factors to:

Rejuvenate skin texture, tone, and elasticity
Promote hair growth and stimulate hair follicles
Accelerate wound healing
Improve the appearance of fine lines and wrinkles

However, PRP and PRF therapy aren’t the same, and the differences give PRF treatments a distinct advantage.

Take a moment to learn about three key differences and how PRF therapy can help you.

Difference #1: PRF uses a natural concentration process

A significant difference between PRF and PRP therapy is the way they are processed.

PRF is created using a slower, less aggressive centrifugation process compared to PRP. This method allows for a higher concentration of platelets, white blood cells, and fibrin — all essential for healing and regeneration.

What’s more? Unlike PRP therapy, which often uses anticoagulants to prevent your blood from clotting while the solution is prepared, PRF doesn’t require any anticoagulants or additives, making it a 100% natural treatment.

Plus, the slower centrifugation in PRF leads to the formation of something called a fibrin matrix. This matrix acts like a scaffold, gradually releasing growth factors over time, which enhances your healing and rejuvenation process.

Difference #2: PRF gives you longer-lasting results

The fibrin matrix in PRF supports the gradual release of growth factors and helps sustain the treatment’s effects for a more extended period compared to PRP.

This means the regenerative effects continue over an extended period. Translation? The prolonged action gives you longer-lasting results in both skin and hair treatments.

In addition, the presence of white blood cells and stem cells in PRF further enhances the healing process, providing you with more noticeable and lasting improvements in your tissue regeneration.

Difference #3: PRF offers a higher concentration of beneficial cells

Finally, PRF contains a higher concentration of beneficial cells, including:

Platelets
Leukocytes (white blood cells)
Mesenchymal stem cells

Leukocytes and stem cells play an important role in tissue repair and regeneration. Their higher concentration in PRF means more effective treatment outcomes, especially for more challenging conditions like significant hair thinning or deeper skin rejuvenation.

The higher platelet count in PRF leads to a more potent treatment. That means PRF therapy can address a wider range of concerns, from minor skin imperfections to more severe hair loss — especially when used with fillers or dermaneedling techniques.

Ready to learn if PRF therapy is for you?

At HK Dermatology, we understand that everyone has unique needs. That’s why our board-certified dermatologists provide personalized guidance to determine if PRF therapy is the right choice for you.

We evaluate your skin or hair condition, discuss your goals, and create a tailored PRF treatment plan that best suits your needs.

Depending on your aesthetic goals, we may recommend PRF injections with or without dermal fillers, dermaneedling with PRF, and PRF scalp treatments.

Wherever it’s used, PRF therapy offers natural and long-lasting results without the use of synthetic additives, making it a safe and effective solution.

Ready to explore the benefits of PRF therapy? Schedule a consultation with a provider at HK Dermatology in San Juan Capistrano, California.